It’s not just weight—it’s war. Deep belly fat, also called visceral fat, may be silently fueling aggressive endometrial cancer in women. A new study presented at the 38th Annual congress of the european Association of Nuclear Medicine (EANM 2025) reveals a terrifying truth: it’s not how much belly fat you have, but how metabolically active it is. This fat burns sugar for energy, communicates with tumors, and could make cancer spread faster. For millions of women worldwide, this isn’t just science—it’s a warning sign.

1. Active Fat vs Passive Fat
Not all fat is equal. While subcutaneous fat (under the skin) is relatively harmless, visceral fat surrounds vital organs, producing hormones and inflammatory chemicals. When this fat is metabolically “hot,” it can accelerate cancer growth.

2. Advanced cancer Linked to Hot Fat
In a study of 274 women with endometrial cancer, scientists found that those whose visceral fat burned more glucose were far more likely to have advanced-stage disease and lymph node metastases. The amount of fat didn’t matter—its activity did.

3. Chronic Inflammation: Fuel for Tumors
Hot belly fat releases inflammatory chemicals that create a perfect storm for tumors to thrive, invade tissues, and resist the body’s natural defenses.

4. insulin Resistance Feeds Cancer
Metabolically active visceral fat can make the body insulin-resistant. High insulin levels provide energy for cancer cells, essentially “feeding the fire” inside the body.

5. Fat Talks to cancer Cells
Through adipokine signaling, fat cells actively communicate with cancer cells, helping them survive and spread. This sinister “conversation” may explain why aggressive cancer often appears in women with metabolically active visceral fat.

6. Implications for Screening and Treatment
This discovery could transform cancer care. Doctors may soon use PET/CT scans to measure fat activity, not just data-size, and develop therapies to “cool down” dangerous visceral fat—potentially slowing tumor growth.

7. A Wake-Up Call for women Worldwide
Obesity isn’t just about appearance—it’s about biology, metabolism, and survival. women with high visceral fat must be aware that their health risks go far beyond numbers on a scale. Metabolically active belly fat may be one of the deadliest hidden threats to women’s health.

⚡Final Blow: Deep belly fat isn’t just storage—it’s a cancer ally. Understanding, monitoring, and controlling metabolically active visceral fat could be the key to stopping aggressive endometrial cancer before it spreads.